| Customization: | Available |
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| Certification: | BRC, ISO, FDA |
| Assay Method: | HPLC, UV |
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I. Chemical Structure and Properties \
Alpha-Ketoglutaric acid AKG
1. Structural Characteristics - It is an α - keto acid, and its chemical name is 2 - oxoglutaric acid. Its chemical formula is C5H6O5.
2. Physical Properties - It is usually a white crystalline or crystalline powder. It is soluble in water, slightly soluble in ethanol, and insoluble in ether. It has a certain acidity because the carboxyl group in its molecule can ionize hydrogen ions.
II. Role in Organisms
1. Role in the Tricarboxylic Acid Cycle (TCA Cycle) - In the aerobic metabolism process of cell respiration, α - ketoglutaric acid is a key intermediate product of the tricarboxylic acid cycle. It is generated by the oxidative decarboxylation of isocitric acid under the action of isocitrate dehydrogenase. Then, α - ketoglutaric acid continues to participate in subsequent reactions and undergoes oxidative decarboxylation reaction catalyzed by the α - ketoglutarate dehydrogenase complex to generate succinyl - CoA. This process produces reduced coenzyme I (NADH) and carbon dioxide. NADH can enter the electron transport chain to produce ATP (adenosine triphosphate). - For example, in the mitochondria of the human body, the TCA cycle is constantly operating, and α - ketoglutaric acid is like a "transfer station", promoting the process of energy metabolism and providing energy for cells.
2. Amino Acid Metabolism - α - ketoglutaric acid is also very important in the synthesis and catabolism of amino acids. It can be interconverted with some amino acids through transamination. For example, a reversible transamination reaction can be catalyzed by glutamate dehydrogenase between glutamate and α - ketoglutaric acid. In this reaction, glutamate loses an amino group and becomes α - ketoglutaric acid, and at the same time, α - ketoglutaric acid gains an amino group to generate glutamate, which plays a key role in maintaining the balance of amino acids in the body.
3. Association with Other Metabolic Pathways - It is also related to some other metabolic pathways. For example, in the process of glutamine synthesis, α - ketoglutaric acid can participate as a raw material. In some tissues, glutamine synthetase uses glutamate and ammonium ions and consumes α - ketoglutaric acid to synthesize glutamine, which is of great significance for the transport and metabolism of ammonia.
Technical Specification:
| ltem | Specification | Result | Method |
| Assay | >99.00% | 99.50% | HPLC |
| B1Afatoxin B1 | ≤5.0ppb | Conforms | LCMS |
| Appearance | Fine Powder | Conforms | Organoleptic |
| Color | White Powder | Conforms | Organoleptic |
| Odor&Taste | Characteristic | Conforms | Organoleptic |
| Physical&chemical Characteristics | |||
| Particle Size | 95%Through 80 mesh | Conforms | Sieving |
| Loss on Drying | ≤5.0% | 3.80% | USP<731> |
| Ash | ≤5.0% | 3.20% | USP<561> |
| Loose Density | Actual Value | 0.51g/'ml | USP<616> |
| Tight Density | Actual Value | 3.20% | USP<616> |
| Residual Solvents | Actual Value | 0.51g/ml | USP<467> |
| Pesticide Residue | Actual Value | 0.69g'ml | USP<561> |
| Heavy Metals | ≤10ppm | Conforms | USP<231> |
| Lead(Pb) | ≤1.0ppm | Conforms | USP<730> |
| Arsenic(As) | ≤1.0ppm | Conforms | USP<730> |
| Mercury(Hg) | ≤0.1ppm | Conforms | USP<730> |
| Cadmium(Cd) | ≤1.0ppm | Conforms | USP<730> |
| MicrobiologicalTests | |||
| Total plate Count | <5000cfu/g | Conforms | USP<2021> |
| Ycast& Mold | ≤100cfu/g | Conforms | USP<2021> |
| E.Coli. | Negative | Negative | USP<2022> |
| Salmonella | Negative | Negative | USP<2022> |
| Staphylococcus | Negative | Negative | USP<2022> |
| Conclusion | Confomm to In-house standard | ||
Delivery:Sea/Air Shipping & International Express
Shipping Time:15 working days after payment
Package: 1-5kg/Aluminum foil bag, size: 22cm (Width)*32cm (Length)
15-25kg/Drum, size: 35cm (Diameter)*51cm (Height)
Storage: Kept away from strong light and heat.
Shelf Life: 24 months
1.Free sample
2.Owning cultivation base as 100% Natural material stable source.
3.Manufacturer direct supply, Powerful R&D team and advanced test center
4.Leading plant extract manufacturer in China.
5.No excuse return of goods
6.OEM & ODM is available
FAQ
Q&A
Q1: How to confirm the Product Quality before placing orders?
A: By sending you our available samples.
Or if you have special requirement on the goods, we can prepare samples according to your requirement for your confirmation.
Q2: Can you supply free samples?
A: Yes, we can provide some free sample, but the shipping cost should be on the customers' account. You can either pay the shipping cost or arrange a courier to collect the samples.
Q3: What's the MOQ?
A: For the high value product, our MOQ starts from 1g and generally starts from 10g.
For other low value product, our MOQ starts from 100g and 1kg.
Q4: How to place order and make payment?
A: You can send our your Purchase order(if your company has), or just send a simple confirmation by email or by TradeManager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.
Q5: How do you treat quality complaint?
A: All our products are strictly tested by our QC, and confirmed by QA; unqualified material will not be released to customer.
In case any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment
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